Crystallization, a common step used during the synthesis of organic compounds to isolate and purify the desired product, is the focus of a white paper from Mettler Toledo. The cooling rate influences crystal size and shape.

The paper discusses how process chemists are applying simple process analytical technology (PAT) tools to:  identify polymorphs during crystallization development; recognize and address oiling out (phase separation); understand factors affecting crystal size, shape and structure; and measure the influence of cooling rate on crystal size and shape.

Download the paper here.