COVID-19 vaccine candidates being developed by Moderna Inc. and BioNTech and Pfizer Inc. will require stringent standards for refrigeration, according to a story on MarketWatch. Such requirements could hinder how they are distributed.

Executives from Moderna and Pfizer separately told the Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practice that mRNA-1273, which is Moderna’s coronavirus vaccine candidate, requires a storage temperature of -4°F. BioNTech and Pfizer’s candidates, BN1162b2 and BNT162b2, need to be stored at -94°F.